Abstract
Leukocyte adhesion deficiency type III (LAD-III) is a rare autosomal recessive disorder characterized by immune dysfunction and bleeding tendencies. The condition arises from mutations in the FERMT3 gene, which disrupts integrin activation on leukocytes and platelets. This case study focuses on a family with consanguineous parents and multiple affected individuals spanning two generations, all diagnosed with LAD-III due to a novel homozygous mutation in the FERMT3 gene (c.1683-22_1683-19del). Clinical manifestations ranged from mild ecchymosis to severe bleeding necessitating transfusions. The proband, a two-year-old male child, presented with recurrent ecchymosis, neonatal sepsis, and thrombocytopenia. His laboratory results included leukocytosis and microcytic hypochromic anemia with normal coagulation profiles. The diagnosis of LAD-III was confirmed through whole exome sequencing that identified the homozygous FERMT3 mutation. Additionally, the proband's 15-year-old sister, who had been earlier diagnosed with Glanzmann thrombasthenia, was found to carry the same mutation, as were the proband's cousin and the cousin of his father.