Abstract
BACKGROUND/OBJECTIVES: The 1742-1743 plague epidemic had a profound impact on populations along the Royal Road (Camino Real), the principal trade route connecting Buenos Aires and Lima. This study aimed to quantify the demographic and socioeconomic consequences of the epidemic in Cordova and Santa Fe, with a focus on excess mortality and its broader implications for marginalized groups. METHODS: This research utilized parish death records and complementary historical sources to calculate excess mortality in Cordova and Santa Fe during the epidemic. Mortality rates were compared across pre-epidemic (1740-1741), epidemic (1742-1743), and post-epidemic (1744-1745) periods. Additional data on demographic variables such as age, gender, marital status, and ethnicity were analyzed to identify patterns of vulnerability and resilience. RESULTS: Excess mortality during the epidemic was significant, with death rates in Cordova peaking at 12 times the pre-epidemic average in May 1743, while Santa Fe experienced a 45% increase in mortality, peaking in December 1743. Marginalized groups, including enslaved and Indigenous populations, were disproportionately affected, exacerbating existing social inequalities. The epidemic also disrupted socioeconomic structures and highlighted systemic vulnerabilities in both urban centers. CONCLUSIONS: This study demonstrates the critical role of excess mortality as a metric for understanding the demographic and socioeconomic impacts of historical epidemics. By integrating quantitative and qualitative analyses, it underscores the intersection of public health crises with social structures in colonial Latin America. The findings offer insights into resilience and recovery mechanisms relevant to both historical and contemporary public health strategies.