Selective Inhibitors of Toll-Like Receptor 9 (TLR9) Could Potentially Treat Fibrotic, Autoimmune, and Inflammatory Diseases

选择性抑制 Toll 样受体 9 (TLR9) 的药物可能用于治疗纤维化、自身免疫性和炎症性疾病

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Abstract

The invention in this patent application relates to imidazopyridinyl derivatives represented herein generally by Formula 1. These compounds are inhibitors of TLR9, and may potentially be useful in treating, preventing, or slowing fibrotic diseases including nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), idiopathic pulmonary fibrosis (IPF), primary sclerosing cholangitis (PSC), and primary biliary cirrhosis (PBC).

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