Abstract
BACKGROUND: Meningioma, a common and mostly benign intracranial and spinal tumor, can coexist with other malignant tumors. Such a scenario is very rare in patients with no history of radiation therapy or phakomatosis. In this study, the authors present three cases of concurrent/adjacent CNS tumors, review the literature on this topic, and highlight some genomic alterations in that regard. OBSERVATIONS: The authors present three cases of patients who had coexistence of meningioma with other glial tumors in this study. LESSONS: Coexistence/collision of intracranial and spinal meningiomas with another CNS pathology occurs anecdotally. This phenomenon does not necessarily preclude resection of both tumors in a single session, provided that a careful preoperative assessment of the surgical anatomy is undertaken. Conducting studies to evaluate the genomic structures of such cases and to explain why they occur in adjacency could be valuable in explaining this phenomenon. https://thejns.org/doi/10.3171/CASE24805.