Abstract
Background: Despite considerable research on pregnancy outcomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the consequences for infants exposed to the virus in utero remain unclear. Methods: A retrospective cohort study was conducted, encompassing 392 mother-infant pairs delivered between April 2020 and July 2021 at a community hospital network in northeastern Pennsylvania, USA. Of these, 198 mothers had a confirmed SARS-CoV-2 infection during pregnancy, while 194 did not. Infant outcomes were compared between the two groups. Results: Pregnant women with a SARS-CoV-2 infection during their gestation exhibited higher rates of obesity (p = 0.04) with higher body mass indices (BMI) (p = 0.01), were more likely to be of Hispanic ethnicity (p = 0.01), and had a history of chronic hypertension (p = 0.05), as well as higher occurrences of postpartum depression (p = 0.01), gestational diabetes (p = 0.05), cesarean section (CS) rates (p< 0.001), and preeclampsia (p = 0.04). Among the infants reviewed, there was no statistical significance difference in developmental milestones at 2, 4, 6, 9, and 12 months of age between infants of parturients who tested positive for coronavirus disease 2019 (COVID-19) and infants of parturients without a positive COVID-19 test result. There was no statistically significant difference between the two groups in developmental outcomes, as measured by Ages and Stages Questionnaire (ASQ) scores at 9 months (p = 0.76) and at 18 months (p = 0.89). Conclusions: This study corroborates the adverse impact of SARS-CoV-2 infection on pregnant women, characterized by increased maternal comorbidities and adverse birth outcomes. No significant disparities in neonatal developmental milestones or growth outcomes were observed at birth; first office visit, or at 1, 2, 4, 6, 9, and 12 months of age.