Perfluorooctanoic acid serum concentrations and half-lives in a community exposed to contaminated drinking water in New York State

纽约州某社区居民饮用受污染饮用水后血清中全氟辛酸的浓度和半衰期

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Abstract

BACKGROUND: Investigations during 2014-2016 in two communities in New York State showed perfluorooctanoic acid (PFOA) in a public system serving 3800 residents (Hoosick Falls) averaging 534 ppt and in a smaller system serving 200 residents (Petersburgh) averaging 92.5 ppt. Bottled water (2015-2016) was provided until filtration brought PFOA levels to non-detectable (2016-2017). OBJECTIVE: The New York State Department of Health (NYSDOH) sought to address community questions about exposures and evaluate reductions in serum concentrations. METHODS: NYSDOH tested serum PFOA in 2016 just after drinking water exposure mitigation and again in 2018. Descriptive statistics for serum PFOA by sex, age, length of residence, and water consumption were evaluated using multiple regression, and half-lives were estimated. RESULTS: Using the serum PFOA GM and median for tests occurring within 3 months of exposure mitigation (N = 1121) (47.5, 54.2) produced serum to water ratios of 89.0 and 101.6. A total of 1573 Hoosick Falls public water consumers (337

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