Abstract
OBJECTIVE: To investigate the association between hysterectomy and accelerated aging, with a focus on the mediating effect of renal function and protective role of dietary fiber intake. METHODS: The cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2010. The effects of serum creatinine, dietary fiber, vitamin C and vitamin D intake were evaluated. RESULTS: A total of 4974 participants were included in this study, and 1151 women accepted hysterectomy. The rates of accelerated aging of the women accepted hysterectomy were significantly increased (13.55% vs 10.62%, p = 0.007), and their levels of serum creatinine were also significantly increased (75.56 vs 66.41, p < 0.01). Logistic regression analysis confirmed that the risk of accelerated aging of women undergoing hysterectomy increased significantly (OR 1.32, CI 1.08, 1.60, p = 0.0060). A nonlinear (L-shaped) relationship was observed between creatinine and the odds ratio by RCS curves. Mediation analysis demonstrated that creatinine accounted for 16.7% of observed association between hysterectomy and accelerated aging (p = 0.044). Additionally, the accelerated aging after hysterectomy would be reduced with the intake of dietary fiber, and it accounted for 5.92% of the association between hysterectomy and accelerated aging (p = 0.05). CONCLUSION: Women who underwent hysterectomy will face the increased risk of accelerated aging, with a focus on renal function as a mediating factor and dietary fiber intake as a potential protective factor. It will contribute to the long-term health management after hysterectomy.