Abstract
The selection of anesthetic drugs in the preparation of an acute myocardial infarction (AMI) model is very important. We specifically focus on various effects of sevoflurane and isoflurane in a murine AMI model, which have not been previously compared. Furthermore, we evaluated success of our AMI model using following methods: echocardiography, TTC staining, and PCR testing. The results show that compared to the isoflurane group, the sevoflurane group mice had shorter anesthetic induction(66.40 ± 2.90S vs. 125.10 ± 6.30S P < 0.0001) and recovery times(28.00 ± 1.07S vs. 56.88 ± 4.14S, P < 0.0001), lower incidence of respiratory depression (0 % vs. 50.00 %, P = 0.0325), and more successful models (93.33 % vs. 60.00 %, P = 0.0801). There were no significant differences in cardiac function, infarction area(49.41 ± 4.18 % vs. 48.66 ± 3.79 %, P = 0.5266), or inflammatory factors in the myocardial infarction area between the two groups. Sevoflurane may therefore be a better choice for the establishment of AMI models in mice.