Abstract
Multiple eruptive dermatofibromas (MEDF) is a rare dermatological condition characterized by the sudden appearance of multiple benign skin lesions, often associated with systemic or autoimmune conditions. This case series describes three female patients with MEDF, highlighting their distinct clinical features and systemic associations. Diagnoses were confirmed through consistent histopathological findings, demonstrating the importance of integrating clinical, dermoscopic, and histopathological evaluations in diagnosing MEDF. The differential diagnosis included other dermatological conditions with overlapping features, which were excluded based on clinical and pathological findings. This report emphasizes the potential role of immune dysregulation and genetic predisposition in MEDF pathogenesis. It underscores the need for further research to understand its mechanisms better, improve diagnostic accuracy, and establish standardized management approaches.