Abstract
Matching is a commonly used causal inference study design in observational studies. Through matching on measured confounders between different treatment groups, valid randomization inferences can be conducted under the no unmeasured confounding assumption, and sensitivity analysis can be further performed to assess robustness of results to potential unmeasured confounding. However, for many common matched designs, there is still a lack of valid downstream randomization inference and sensitivity analysis methods. Specifically, in matched observational studies with treatment doses (eg, continuous or ordinal treatments), with the exception of some special cases such as pair matching, there is no existing randomization inference or sensitivity analysis method for studying analogs of the sample average treatment effect (ie, Neyman-type weak nulls), and no existing valid sensitivity analysis approach for testing the sharp null of no treatment effect for any subject (ie, Fisher's sharp null) when the outcome is nonbinary. To fill these important gaps, we propose new methods for randomization inference and sensitivity analysis that can work for general matched designs with treatment doses, applicable to general types of outcome variables (eg, binary, ordinal, or continuous), and cover both Fisher's sharp null and Neyman-type weak nulls. We illustrate our methods via comprehensive simulation studies and a real data application. All the proposed methods have been incorporated into $\tt {R}$ package $\tt {doseSens}$.