Abstract
Artificial intelligence (AI) is rapidly transforming medical education and practice, challenging the cognitive role of physicians, and raising concerns about their future relevance. While this potential disruption sparks fear, it is also an unprecedented opportunity. Healthcare faces significant challenges - inequities, inefficiencies, and gaps in quality - that AI could help address. Instead of fearing change, physicians must take the lead in shaping the AI-integrated future of healthcare for the benefit of patients and society. Physicians, with their deep understanding of patient needs and systemic challenges, must lead this transformation - starting with medical education. The next generation of physicians should be prepared not just to work alongside AI, but to drive its development in ways that enhance patient outcomes and uphold medical ethics. This Eye opener, authored by medical educators and students with diverse perspectives, proposes foundational skills for all physicians, including AI literacy, critical appraisal of AI-generated outputs, ethical considerations, and resilience in AI-independent decision-making. Beyond these core competencies, they outline specialized AI educational pathways - ranging from technical expertise to health system transformation and precision medicine - to prepare healthcare professionals for leadership in an AI-integrated future. Designing these curricula will require innovative collaboration with technological experts, data scientists, policymakers, clinicians, and educators. This educational reform demands systems thinking, interdisciplinary collaboration, faculty development, robust assessment frameworks, global perspectives, and a commitment to lifelong learning. Delaying this work risks ceding control of AI's role in medicine to entities that may not always prioritize patient welfare. The future of AI-integrated healthcare will be shaped by those who take initiative. Medical educators must guide and train students to lead AI's transformative potential, ensuring that technological advancements are leveraged for the benefit of patients and society. The time to act is now.