Abstract
RATIONALE: Superficial angiomyxoma (SA) is a rare benign tumor that occurs in the superficial dermis or subcutaneous tissue. It is characterized by a significant presence of mucous matrices and blood vessels. In case reports, nodules typically appear on the trunk, head, and limbs. We conducted a search of PubMed, Embase, the Cochrane Library, and other medical databases, finding only a limited number of case reports. Here, we present the case of a 43-year-old male with paratesticular SA, and share our therapeutic experience. PATIENT CONCERNS: A 43-year-old man was admitted to the hospital due to an enlarged scrotum. DIAGNOSES: We surgically excised the mass. Histopathological examination using hematoxylin and eosin staining revealed abundant myxoid stroma. Immunohistochemical staining was performed to establish a differential diagnosis of deep (aggressive) angiomyxoma. Staining for CD34, desmin, estrogen receptor, and vimentin was positive, while S-100 was negative. Based on these findings, the patient was diagnosed with SA. INTERVENTIONS: In our case, the tumor boundary was well-defined, and we successfully removed it in its entirety. OUTCOMES: We have been monitoring the patient for 3 years, and there has been no recurrence of the condition. LESSONS: To prevent the recurrence of SA, complete resection is recommended, including partial resection of normal tissue.