Abstract
RATIONALE: Gastrointestinal stromal tumors (GISTs) in the duodenum are usually very rare, accounting for only 3% to 5% of all GISTs. Giant duodenal GISTs with a more than 10 cm diameter are even rarer, and there is currently no consensus on their treatment. This article reports a case of successful treatment of a giant duodenal GIST. PATIENT CONCERNS: A 59-year-old woman presented with mid-upper abdominal pain accompanied by nausea and bloating. We underwent contrast-enhanced abdominal computed tomography scans and computed tomography-guided fine needle aspiration biopsy. DIAGNOSES: The final diagnosis was duodenal GIST with a risk stratification of high-risk. INTERVENTIONS: After a multidisciplinary team discussion, the patient underwent a combination of targeted-surgical-targeted therapy. OUTCOMES: The patient ultimately achieved R0 resection at surgery, and no recurrence was noted during the follow-up period. LESSONS: Targeted-surgery-targeted combined therapy is one of the effective means for giant duodenal GIST. At the same time, genetic testing before neoadjuvant therapy is crucial for guiding treatment and is strongly recommended as a basic examination method.