Abstract
C(sp(3))-H bond functionalization is a powerful strategy for the synthesis of organic compounds due to their abundance in simple starting materials. Photoredox catalysis has led to a diverse array of enabling C(sp(3))-H activation strategies; however, a general platform for the direct functionalization of C(sp(3))-H to carboxylic acid derivatives remains elusive. Disclosed herein is the development of a cooperative NHC/photoredox-catalyzed C(sp(3))-H esterification transformation. This method enables access to benzylic, α-heteroatom, and formal β-esterification products in good to excellent yields under mild reaction conditions.