IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

IMM0306 是一种 CD20 mAb 与 SIRPα 的 CD47 结合域的融合蛋白，可通过同时与 B 细胞的 CD47 和 CD20 结合，阻断 CD47-SIRPα 相互作用和 FcɣR 结合，激活巨噬细胞和 NK 细胞，发挥出色的杀伤癌症功效