Abstract
BACKGROUND: Vitiligo in hair bearing areas, especially segmental vitiligo, is frequently associated with leukotrichia. Leukotrichia, in general, is considered a predictor of unsatisfactory response to conventional treatment methods like phototherapy. This review aims to systematically review various available treatment options in patients with eyebrow and eyelash leukotrichia and assess the response to these therapeutic modalities. MATERIALS AND METHODS: Articles were searched using the keywords "eyelid", "eyelash", "leukotrichia", either singly or combined. The databases searched include Pubmed, Cochrane Library, Embase, and Science Direct. The strategy was to include studies in which any therapeutic modalities were undertaken for treatment of eyelash or eyebrow leukotrichia. RESULTS: After applying the inclusion and exclusion criteria, this review included 15 studies. There was a positive response to the surgical treatment options for eyebrow and eyelash leukotrichia. Topical tofacitinib has emerged as a promising new therapeutic option, but further studies are needed to establish its efficacy. CONCLUSION: In conclusion, there are several treatment options for eyebrow and eyelash leukotrichia. However, further studies are needed to better understand their efficacy and optimal applications.