Abstract
Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) and its association with lacrimal drainage disorders are well known. EECS has p63 gene mutations which affect the ectodermal, orofacial, and limb development along with developmental delay affecting the entire body. Complex lacrimal drainage anomalies typically require endoscopic guidance through the nose for successful outcomes. p63 gene mutations affect the nasal structural development, making the surgical access as well as the outcomes in complex lacrimal drainage disorders difficult to predict and achieve. The present case describes a multidisciplinary approach of the oculoplastic and rhinology services in managing a complex lacrimal drainage disorder.