Abstract
OBJECTIVE: To evaluate the clinical effects of concentrated growth factor (CGF) combined with Bio-Oss bone powder on guided bone regeneration for the maxillary posterior region. METHODS: This retrospective study included 32 patients with missing maxillary posterior teeth and severe alveolar ridge atrophy requiring implant restoration for retrospective analysis. Sixteen patients received CGF combined with Bio-Oss treatment (CGF/Bio group), while the remaining 16 received Bio-Oss treatment only (Bio group). The Bio group used Bio-Oss bone powder directly. Cone-beam computed tomography (CBCT) was performed preoperatively and at 2, 4, and 6 months postoperatively to evaluate bone mineral density (HU values). The implant retention rate, soft tissue healing time, postoperative pain, and swelling were also evaluated. RESULTS: The 1-year implant retention rate was 100% in the CGF/Bio group and 81.25% in the Bio group (P = 0.054). Soft tissue healing time was significantly shorter in the CGF/Bio group (P = 0.122). Bone density was significantly higher in the CGF/Bio group at 2, 4, and 6 months postoperatively (P < 0.05). Postoperative pain and swelling were significantly lower in the CGF/Bio group (P = 0.008 and P = 0.014, respectively). CONCLUSION: The combined application of CGF and Bio-Oss bone powder in maxillary sinus external lift demonstrates superior clinical outcomes, offering improved bone augmentation and enhanced postoperative healing compared to Bio-Oss bone powder alone.