Abstract
Carpal tunnel syndrome (CTS) is a comorbid condition often seen in patients with acromegaly. It often causes neuropathy that is severe enough to require the patient to undergo median nerve release surgery multiple times. Excessive growth hormone secretion will cause end-organ damage in the patient and will manifest itself with different complaints. The degree of complaints will decrease with early diagnosis and treatment of acromegaly. This case highlights the natural course of CTS associated with acromegaly and the importance of questioning the etiology in CTS. When the primary disease is treated, the patient's functionality will improve.