Abstract
INTRODUCTION: Nonhealing or rapidly growing lesions should raise suspicion for malignancy, especially in a patient with a prior history of cancer. The purpose of this case was to highlight the importance of a thorough clinical history. A high index of suspicion and low threshold for biopsy are important, as is a fast diagnosis, as they can make a difference in adequate treatment and prognosis. CASE PRESENTATION: We present a case of a 46-year-old female with a history of invasive ductal carcinoma of the breast presenting with a rapidly growing painless right lower eyelid lesion with biopsy remarkable for a high-grade neuroendocrine carcinoma suspected to be a result of metastasis with rare transformation of breast ductal carcinoma. CONCLUSION: She had an eyelid lesion recurrence less than 2 months after biopsy and excision, demonstrating the importance of early detection and biopsy with immunohistochemistry to target malignant cells and improve life quality and expectancy.