Abstract
Ultra-high magnetic fields and high-sensitivity cryoprobes permit the achievement of a high S/N ratio in (13)C detection experiments, thus making a (13)C superWEFT (Super water eliminated Fourier transform) experiment feasible. (13)C signals that are not visible using (1)H observed heteronuclear experiments, nor with established 2D (13)C direct detection experiments, become easily observable when a (13)C relaxation-based filter is used. Within this frame, optimal control pulses (OC pulses) have been, for the first time, applied to paramagnetic systems. Although the duration of OC pulses competes with relaxation, their application to paramagnetic signals has been successfully tested. OC pulses are much more efficient with respect to the phase- and amplitude-modulated ones routinely used at lower fields while providing bandwidth excitation profiles that are sufficient to meet the need to cover up to an 80 ppm spectral region. On the other hand, when paramagnetic relaxation is shorter than the duration of OC pulses, the use of hard, rectangular pulses is, at the present state of the art, the best approach to minimize the loss of signal intensity.