Abstract
Gitelman syndrome (GS) is a rare autosomal recessive salt-losing tubulopathy caused by mutations in the SLC12A3 gene, leading to hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. We present a case series of two patients with GS, both presenting with seizures, a rare manifestation, alongside distinct atypical features. Case 1, a 35-year-old male, exhibited tetanic spasm, hypocalcemia, secondary hyperparathyroidism, and basal ganglia calcification. Case 2, a 55-year-old male with a history of coronary artery disease, presented with seizure, hypomagnesemia, and hyponatremia. These cases highlight the clinical heterogeneity of GS, emphasizing the importance of considering atypical presentations and their implications for diagnosis and management.