Abstract
Myosin heavy chain 9-related disorders (MYH9RD) are rare autosomal dominant genetic conditions caused by MYH9 mutations, leading to macrothrombocytopenia, renal complications such as focal segmental glomerulosclerosis (FSGS), and other systemic manifestations. We report a case of 28-year-old male with MYH9RD and body mass index exceeding 47 kg/m(2), who successfully underwent laparoscopic sleeve gastrectomy. Despite challenges from bleeding tendency caused by macrothrombocytopenia and renal impairment caused by FSGS, thorough preoperative evaluation and management, including platelet transfusion, enabled surgery to proceed without complications. The patient achieved significant weight loss, from 147.6 kg preoperatively to 90.15 kg at 1 year postoperatively, with improvements in hypertension and metabolic parameters, including aspartate aminotransferase/alanine aminotransferase, hemoglobin A1c, triglycerides, and low-density lipoprotein levels. While MYH9RD is not directly associated with morbid obesity, this case highlights that comprehensive preoperative evaluation and risk management can lead to successful outcomes in bariatric surgery for MYH9RD patients.