Abstract
Guillain-Barré syndrome (GBS) is an acute, immune-mediated disease that can be potentially life-threatening. The classic presentation of GBS, characterized by the onset of progressive and ascending muscle weakness following an infectious process, is usually recognized promptly. However, atypical variants with unusual presentations may pose significant diagnostic challenges, resulting in delayed diagnosis and an increased likelihood of unfavorable outcomes. Emerging reports have explored potential associations between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and GBS, though the mechanisms underlying these connections remain uncertain. We present the case of a 60-year-old man diagnosed with an atypical form of GBS in the context of COVID-19 infection.