Abstract
Gait symmetry between both legs is a typical hallmark of healthy walking. In contrast, several pathologies induce asymmetry in the gait pattern, regarding both spatial and temporal features. This can be due to either an asymmetrical change of the body morphology-e.g., after an amputation or an injury-or a damage in the brain-such as stroke or cerebral palsy. This deficit in gait symmetry usually induces higher metabolic effort in locomotion and might further accelerate severe comorbidities such as osteoarthritis and low back pain. Consequently, several assistive devices-such as active exoskeletons or prostheses-are currently developed to mitigate gait asymmetry and restore a healthier gait pattern. Typically, the development of such devices requires extensive tests and validations, and it is practically and ethically not always desirable to recruit disabled patients to run these tests in the preliminary stages of development. In this review paper, we collect and analyse the different reversible interventions described in the literature that can induce asymmetry in the gait pattern of healthy walkers. We perform a systematic literature research by exploring five databases, i.e., Pubmed, Embase, Web of Science, Google Scholar, and Scopus. This narrative review identifies more than 150 articles reporting 16 different interventional methods used to induce asymmetric gait pattern in healthy walkers or with the potential to do so. These interventions are categorized according to their mode of action, and their effects on spatiotemporal parameters, joint kinematics and kinetics are summarized adopting a macroscopic viewpoint. Interventions are compared in terms of efficacy, maturity of the results, and applicability. Recommendations are provided for guiding researchers in the field in using each of the identified manipulations in its most relevant research contexts.