Abstract
INTRODUCTION: Mesothelioma is a rare malignancy of the serous membranes, most commonly the pleura. Variations and demographic trends in mesothelioma incidence form the basis of this study. METHODOLOGY: A retrospective study was conducted on August 30, 2024, using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. The study analyzed age, gender, and race of mortality among mesothelioma patients in the United States from 1999 to 2020. RESULTS: There was a significant increase in the incidence of mesothelioma from 1999, peaking in 2011, followed by a gradual decline. Incidence was higher among individuals aged ≥75 years, men, and the White population. CONCLUSIONS: This study highlights the higher incidence of mesothelioma in individuals aged ≥75 years compared to younger age groups, in men compared to women, and in White populations compared to other races. Overall, the incidence increased from 1999 to 2010, peaked in 2011, and declined thereafter through 2020.