Abstract
OBJECTIVES: To study the correlation between coagulation function indicators at 28-34 weeks of gestation and the occurrence, progression, and severity of hypertensive disorders in pregnancy (HDP), and to explore their potential predictive value for HDP. By analyzing the changes in coagulation function indicators during pregnancy, HDP can be detected early, the progression of HDP can be delayed, and the prognosis of mothers and infants can be improved. METHODS: This retrospective analysis encompassed 300 pregnant women who underwent antenatal examinations at the obstetrics outpatient department of Jinan Maternity and Child Care Hospital between October 2020 and October 2023. A total of 182 pregnant women diagnosed with HDP were selected as the observation group. Meanwhile, 118 healthy pregnant women from the same period served as the control group. General clinical data of all participants, such as age, gestational age, number of pregnancies, and number of deliveries, were collected. After an overnight fast, blood samples were drawn from all participants and immediately sent for testing to assess coagulation function indicators. Subsequently, these indicators were analyzed to explore their potential predictive value for the occurrence and severity of HDP. RESULTS: Platelet count (PLT), thrombin time (TT), and fibrinogen (Fib) were identified as independent prognostic factors for pregnant women with HDP. Additionally, pregnant women with HDP had a higher incidence of premature delivery, full-term birth, vaginal delivery, cesarean section, postpartum hemorrhage, fetal growth restriction, neonatal asphyxia, and perinatal death. CONCLUSION: PT (Prothrombin Time), activated partial thromboplastin time (APTT), TT, Fib, and international normalized ratio can reflect the severity of hypertensive disorders in pregnancy.