Abstract
Purpose: To describe a novel case of optic disc edema in the setting of VEXAS syndrome. Methods: A single case is evaluated. Results: A 77-year-old man presented with optic disc edema and hemorrhage and was initially diagnosed with relapsing chondritis. Subsequently, he was diagnosed with VEXAS syndrome, which resolved with an increase in immunosuppressive treatment. Conclusions: Patients with VEXAS syndrome may present with a spectrum of ocular manifestations, including optic disc edema.