Abstract
Large pedunculated skin lesions are a rare presentation in primary care settings. In general, these lesions are asymptomatic other than occasional irritation and discomfort. Although differential diagnosis mainly includes benign lesions, an excisional biopsy should be performed, particularly in symptomatic cases. We present the case of a woman in her 40s with an irritating large and pedunculated skin lesion on her back. Due to the symptomatic nature of the lesion, an excisional biopsy was performed, which confirmed the diagnosis of a nevus lipomatosus superficialis.