Abstract
Sarcoidosis, a systemic disorder characterized by non-caseating granulomas, poses diagnostic challenges due to its diverse manifestations. We present a rare case of superior vena cava syndrome (SVCS) secondary to most likely granulomatous involvement in a patient with mediastinal sarcoidosis. While SVCS typically arises from extrinsic compression or thrombosis, our case highlights the importance of considering inflammatory thickening of the SVC wall as a potential cause, requiring appropriate treatment.