Severe Tophaceous Polyarticular Gout: A Case Report and Review of Literature

重度痛风石性多关节痛风:病例报告及文献综述

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Abstract

Gout is a common form of inflammatory arthritis that affects a significant portion of the population. It is characterized by joint pain, tenderness, and morning stiffness which is more common with acute episodes. Gout is associated with the deposition of monosodium urate crystals, a consequence of hyperuricemia, where serum urate concentrations exceed a critical threshold of 6.8 mg/dL. While many patients are underexcreters of uric acid, some progress to tophaceous gout, marked by severe tissue deposits of monosodium urate (MSU) crystals. This condition typically develops after a decade of untreated symptomatic gout but can occasionally be present at initial diagnosis.  In this case, we present a 43-year-old male with a long-standing history of chronic gouty arthritis, who developed an acute exacerbation involving the right shoulder, elbow, and wrist. The patient's work as a cruise line mechanic limited his access to regular healthcare resulting in recurrent gout flares over the past few years, complicated by tophi in all four extremities. Despite initial concerns, the serology was negative for rheumatoid arthritis. His management included colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and long-term urate-lowering therapy with allopurinol with a detailed plan for outpatient follow-up with a rheumatologist. Through this case, we aim to highlight the consequences of delayed treatment, stressing the need for early intervention and consistent management of chronic gout. We identified a significant trend, showing a dramatic increase in hospital admissions for gout flares reflecting broader trends in patient demographics and healthcare management. Factors contributing to this rise include an aging population with a higher prevalence of obesity and metabolic syndrome, as well as suboptimal gout management in both outpatient and inpatient settings. The rising rates of hospitalizations for gout highlight significant gaps in current management practices, despite the availability of effective treatment options. This warrants an urgent need for healthcare providers to implement effective strategies that optimize outpatient care and enhance adherence to treatment protocols, ultimately improving patient outcomes and reducing healthcare burdens.

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