Abstract
Zoonotic diseases pose global public health threats, prompting various interventions to limit their emergence and spread. One increasingly common response by governments has been to ban wildlife hunting, trade and consumption. However, there is limited evidence of the effectiveness of wildlife trade bans. Here we assess compliance with Nigeria's wildlife trade ban-enacted to curb the spread of mpox (formerly monkeypox)-by analysing approximately 4.5 years of wild meat sales data from 19 vendors in southeast Nigeria (988 vendor-months) alongside interviews with vendors and law enforcement officials. After matching the sales data by time of year, we found no significant differences before and after the ban in the number of vendors selling wild meat per week, the weekly mass of wild meat sold, or the weekly price per kilogram of wild meat; however, the total weekly sales price was higher post-ban. These findings, supported by interview insights, indicate widespread non-compliance by vendors, questioning the ban's effectiveness. We propose that successful regulations require clear enforcement mechanisms, active public engagement and economic incentives to improve compliance. This study provides valuable insights for designing effective interventions to mitigate zoonotic spillovers.