Abstract
Acute esophageal necrosis (AEN) is a rare syndrome, characterized by extensive circumferential necrosis of the esophageal mucosa at the gastroesophageal junction. AEN carries significant morbidity and mortality, and early recognition is crucial for management. We present a case series of AEN in two critically ill patients, one who presented with coffee ground emesis and diabetic ketoacidosis (DKA) and the other one who presented with upper gastrointestinal bleed in the setting of malignancy and concurrent infection with active antibiotic use. Prompt diagnosis and management of both AEN and its underlying causes are crucial to improve patient outcomes.