Abstract
We herein report a rare case of catheter-associated methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis in a patient with a central venous access device retained for over 20 years. Diagnosis was delayed due to subtle clinical signs and limitations of initial imaging, but the patient was ultimately treated successfully with percutaneous debulking of the vegetation. This case highlights the risks associated with long-term catheter retention and underscores the importance of multidisciplinary care and innovative percutaneous therapies in high-risk patients.