Decidual stromal cell-derived PGE2 regulates macrophage responses to microbial threat

These data suggest key roles for decidual stromal cells in modulating tissue responses to microbial threat through release of PGE2 .

In response to LPS, dTHESC and THP-1 coculture demonstrated enhancement of most inflammatory mediators, but a potent suppression of macrophage TNF-α generation was observed. This appeared to reflect a paracrine-mediated effect of decidual cell-derived PGE2 . In mice with GBS chorioamnionitis, macrophages accumulated at sites of bacterial invasion with increased PGE2 in amniotic fluid, suggesting such paracrine effects might hold relevance in vivo.