Abstract
Background Chronic pruritus (CP) is a prevalent and distressing condition with a significant impact on patients' quality of life. Despite advances in understanding its pathophysiology, management remains challenging, necessitating insights into dermatologists' perspectives on CP treatment. Objective This study aimed to assess the knowledge, attitudes, and practices (KAP) of dermatologists regarding CP management, with a focus on antihistamine use. Methods A cross-sectional study was conducted among dermatologists across India. A total of 220 participants completed the quantitative KAP questionnaire, while 15 (6.82%) underwent qualitative interviews. Data were analyzed using descriptive statistics and thematic analysis. Results Dermatologists showed good knowledge of CP pathophysiology, with histamine and H1 receptors recognized as key mediators. Antihistamines were widely used, and many respondents reported a shift toward once-daily regimens to improve symptom control and adherence. Patient education was identified as a critical need, alongside further safety and efficacy data in high-risk groups. Conclusion Dermatologists emphasized a patient-centered approach, prioritizing the identification of underlying causes while addressing symptoms. Hydroxyzine and its sustained-release formulation were regarded as convenient and effective, supporting simplified dosing and better adherence. Strengthening patient education remains essential to optimizing CP management.