Abstract
Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the United States (US). However, the trends and disparities in ACS mortality are not well understood. This study aimed to analyze the ACS mortality in the US from 1999 to 2020 using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. The age-adjusted mortality rates (AAMR) due to ACS were calculated for each year from 1999 to 2020, stratified by sex, race, urbanization, and state. The trends and disparities in AAMR were examined using descriptive statistics and graphical methods. The AAMR due to ACS decreased from 1999 to 2010 and for some variables till 2018, but then increased from 2018 to 2020. The AAMR due to ACS was higher in men than in women, non-Hispanic black adults than in non-Hispanic white adults and rural than in urban populations. The AAMR due to ACS varied widely among different states, with New York having the highest AAMR and Minnesota having the lowest AAMR. This study revealed the trends and disparities in ACS mortality in the US from 1999 to 2020. The study showed an increase in AAMR due to ACS in the recent years. The study also found significant disparities in AAMR due to ACS by sex, race, urbanization, and state. Further research is needed to explore the factors that contribute to the variation and inequality in ACS mortality.