Abstract
Background: Normal pregnancy and the postpartum period are characterized by thrombotic predisposition. Consequently, monitoring coagulation markers and conducting risk assessments are essential in preventing thrombotic events that negatively impact both the mother and the child. In medical practice, fibrinogen/fibrin degradation products (FDPs) are the main coagulation markers currently investigated in pregnancy. Methods: We investigated proteins C and S, antiphospholipid antibodies (APLs), human factor V, and beta-2-glycoprotein 1 or apolipoprotein H (APOH) levels to determine whether there is any difference between normal third-trimester pregnancies and pregnant women in late pregnancy who end up developing deep vein thrombosis (DVT). Results: Our data show a significant correlation between protein C levels and the number of weeks of pregnancy, as well as statistically significant differences between healthy pregnant women and pregnant women with DVT in terms of the values of FDP, protein S, and APL. The DVT group had higher FDP levels but lower AFL and protein S values. Conclusions: Given the significant prothrombotic correlation that exists between proteins C and S, we propose that variations in their levels can serve as valuable markers in the evaluation of thrombotic risk during the final stages of pregnancy.