miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma

miR-25 靶向 TNF 相关凋亡诱导配体 (TRAIL) 死亡受体 4 并促进胆管癌细胞凋亡抵抗

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作者:Nataliya Razumilava, Steve F Bronk, Rory L Smoot, Christian D Fingas, Nathan W Werneburg, Lewis R Roberts, Justin L Mott

Conclusion

These data implicate elevated miR-25 levels in the control of tumor cell apoptosis in cholangiocarcinoma. The identification of the novel miR-25 target DR4 provides a mechanism by which miR-25 contributes to evasion of TRAIL-induced cholangiocarcinoma apoptosis.

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