Abstract
IgA nephropathy (IgAN) is currently the most common primary glomerular disease worldwide, and early diagnosis and intervention contribute significantly to improving outcomes and reducing the incidence of renal failure. The pathogenesis of IgAN remains incompletely understood. In recent years, the rapid development of single-cell RNA-sequencing (scRNA-seq) technology has provided the high-resolution and rich data necessary to elucidate disease characteristics and enabled the analysis of complex interactions between individual cells and cell types. The application of scRNA-seq in IgAN successfully revealed the landscape of immunological features, including peripheral blood B-cell and Th-cell activation, cytotoxic T-cell depletion, and renal infiltrating cell subtypes, as well as the crucial role of mesangial cells and endothelial cells in the early stage of kidney injury, and also revealed the extensive intercellular interactions between renal cells. Here, we discuss the research progress of scRNA-seq technology in IgAN. These scRNA-seq profiles help us to understand the complex molecular mechanisms of IgAN and develop biomarkers and specific therapeutic strategies.