Synergistic effects of peripheral inflammation and neuroinflammation on amyloid, vascular, and neurodegeneration markers across the Alzheimer’s disease spectrum

BACKGROUND: Systemic inflammation and astrogliosis are relevant in Alzheimer’s disease (AD). We evaluated whether peripheral inflammation has synergistic effects with astrogliosis on β‐amyloid (Aβ), vascular, and neurodegeneration markers. METHOD: In the Ginkgo Evaluation of Memory Study, we evaluated the relationship between peripheral inflammation (TNF‐R1, TNF‐R2, IL‐6, IL‐2, CRP and sCD14) and astrogliosis (GFAP