Abstract
INTRODUCTION: Inflammation plays a crucial role in the pathophysiology of acute coronary syndrome (ACS). The C-reactive protein-to-albumin ratio (CAR) and uric acid-to-albumin ratio (UAR) are novel markers of systemic inflammation, and their clinical significance has not been elucidated in ACS. AIM: This study aims to evaluate the association between CAR and UAR with the severity of coronary artery disease (CAD) in patients with ACS undergoing coronary angiography, as assessed by the SYNTAX score (SS). MATERIALS AND METHODS: This is a hospital-based cross-sectional study conducted from November 2021 to October 2022. A total of 233 patients with ACS were enrolled in the study, who underwent relevant investigations. Coronary angiograms were used to diagnose the presence of CAD, and its severity was assessed using SS. The correlation between UAR and CAR with CAD severity, as measured by SS, was studied and compared in the study population. RESULTS: The mean age of the study population was 57.17 ± 10.40 years, with average CAR and UAR values of 8.55 ± 11.05 and 1.62 ± 0.47, respectively. Pearson's correlation analysis showed significant positive correlations between CAR and SS (r = 0.779, p < 0.001) and between UAR and SS (r = 0.823, p < 0.001). Univariable logistic regression analysis indicated that C-reactive protein, serum uric acid, UAR, and CAR were significantly associated with an intermediate to high SS (p < 0.001). CONCLUSION: The present study demonstrated a significant association between CAR and UAR with the severity of CAD, as assessed by SS.