Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

丙型肝炎病毒感染会改变干扰素 α 和白细胞介素 28B 诱导干扰素刺激基因的动力学差异

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作者:Nikolaus Jilg, Wenyu Lin, Jian Hong, Esperance A Schaefer, David Wolski, James Meixong, Kaku Goto, Cynthia Brisac, Pattranuch Chusri, Dahlene N Fusco, Stephane Chevaliez, Jay Luther, Kattareeya Kumthip, Thomas J Urban, Lee F Peng, Georg M Lauer, Raymond T Chung

Conclusion

The kinetics of gene induction are fundamentally different for stimulations with either IFN-α or IL28B in hepatocytes, suggesting distinct roles of these cytokines within the immune response. Furthermore, the observed differences are substantially altered by infection with HCV.

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