Abstract
The study aimed to investigate the relationship between the systematic immune-inflammation index (SII) and stroke among American adults using data from the National Health and Nutrition Examination Survey from 2011 to 2020. The SII was calculated as the platelet count multiplied by the neutrophil count divided by the lymphocyte count. Weighted multivariate logistic analysis was used to estimate the relationship between SII and stroke, with subgroup and sensitivity analyses conducted to explore potential moderators and ensure result stability. The findings revealed that a higher SII was associated with increased susceptibility to stroke, particularly in females, after adjusting for covariates. Further prospective studies are needed to investigate the relationship between SII and different subtypes of stroke.