Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium

肝细胞生长因子和表皮生长因子介导的信号在大鼠肝细胞向胆道上皮细胞转分化中的机制

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作者:Pallavi B Limaye, William C Bowen, Anne V Orr, Jianhua Luo, George C Tseng, George K Michalopoulos

Conclusion

Taken together, these data indicate that hepatocyte to BE transdifferentiation is regulated by HGF and EGF receptors and that PI3 kinase-mediated signaling independent of AKT is a crucial component of the transdifferentiation process.

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