Abstract
Deep vein thrombosis (DVT) is a common venous thrombotic disorder. Current treatment strategies focus on anticoagulation and pharmacomechanical thrombectomy technologies; however, associated complications must be considered. Acute kidney injury (AKI) secondary to hemoglobinuria requiring renal replacement therapy is a rare yet serious complication of mechanical thrombectomy with the AngioJet® rheolytic thrombectomy system. This report describes the case of a 47-year-old male patient who developed AKI, hemoglobinuria, and metabolic acidosis within hours of the procedure. Despite fluid administration and urine alkalinization, renal replacement therapy was required; renal function subsequently recovered. This case illustrates the risk of AKI from hemoglobinuria associated with mechanical thrombectomy, plausibly mediated by hemolysis and oxidative stress leading to renal tubular obstruction. Close renal monitoring and individualized risk‑factor assessment facilitate early recognition and timely intervention, potentially mitigating the risk of chronic kidney disease.