Abstract
OBJECTIVES: to assess the utility of the international society on thrombosis and hemostasis (ISTH) bleeding assessment tool a screening questionnaire for diagnosis of Glanzmann thrombasthenia (GT) and its severity. SUBJECTS &METHODS: Out of 250 children, only 30 had GT and were classified into 3 sub-groups by flow cytometric analysis. Thirty age- and sex-matched healthy individuals were compared to the cases. Platelet count, bleeding time, platelet aggregation studies, and flow cytometric analysis were done. RESULTS: Dental extractions, oral cavity bleeding, bruises on the skin, bleeding from small cuts, and epistaxis all exhibited significant increases in the cases as compared to the healthy individuals (p = < 0.001). In comparison to type II and type III, the ISTH-bleeding questionnaire score revealed a significant rise in the type I (p < 0.001). The ISTH-bleeding questionnaire score's AUC revealed that GT cases and healthy individuals could be distinguished with great accuracy (AUC = 1) (CI 95%, P < 0.001). The following values were 100% at the cutoff value of ≥ 3.5: sensitivity, specificity and accuracy. CONCLUSION: It will be helpful to screen cases for suspected bleeding disorders, such as GT using the ISTH bleeding assessment tool questionnaire before undergoing time-consuming examinations. This will also help forecast the severity of various types of GT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12288-025-01994-0.