Three Malagasy Cases of Severe Bone Complications Revealing Primary Hyperparathyroidism

三例马达加斯加严重骨骼并发症病例揭示原发性甲状旁腺功能亢进症

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Abstract

Primary hyperparathyroidism (PHPT) is a metabolic disorder characterized by hypercalcemia with elevated or unsuppressed parathyroid hormone (PTH). It is rare in children but common in adults, particularly in women around the age of 50. In 85% of cases, PHPT is asymptomatic and is diagnosed following hypercalcemia and elevated PTH levels during routine examinations. PHPT occurring before the age of 25 and the normocalcemic phenotype are unusual situations that may delay diagnosis. These nonclassical forms expose patients to severe bone complications that can cause disability. Our objective is to report three clinical cases of PHPT revealed by catastrophic skeletal deformities and pathological fractures.

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