Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth

胞浆磷脂酶 A2alpha 和过氧化物酶体增殖激活受体 γ 信号通路抵消转化生长因子 β 介导的对原代和转化肝细胞生长的抑制

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作者:Chang Han, William C Bowen, Guiying Li, Anthony J Demetris, George K Michalopoulos, Tong Wu

Conclusion

Our data show that cPLA(2)alpha activates peroxisome proliferator-activated receptor gamma (PPAR-gamma) and thus counteracts Smad2/3-mediated inhibition of cell growth. Therefore, regulation of TGF-beta signaling by cPLA(2)alpha and PPAR-gamma may represent an important mechanism for control of hepatic cell growth and hepatocarcinogenesis.

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