Abstract
BACKGROUND: The triglyceride-glucose (TyG) index has been shown to correlate with cardiovascular risk. This meta-analysis aims to evaluate the incidence of the TyG index on the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary artery disease (CAD). METHODS: A systematic literature search was conducted in the Web of Science, PubMed, and Embase databases from their inception until December 18, 2024. Studies that examined the association between the TyG index and the risk of MACEs in patients with CAD were included. Adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were aggregated using a random-effects model. Statistical analysis was performed using STATA 14.0. RESULTS: A total of 23 studies encompassing 50,793 subjects were ultimately incorporated into this meta-analysis. The findings indicated that an elevated TyG index correlates with an increased risk of MACEs (HR = 1.66, 95% CI [1.47-1.88], P < .0001), all-cause mortality (HR = 1.36, 95% CI [1.12-1.66], P = .002), cardiovascular mortality (HR = 1.44, 95% CI [1.00-2.06], P = .049), myocardial infarction (HR = 1.72, 95% CI [1.33-2.23], P < .0001), stroke (HR = 1.60, 95% CI [1.23-2.07], P < .0001), and revascularization procedures (HR = 1.82, 95% CI [1.41-2.36], P < .0001) among CAD patients. CONCLUSION: This meta-analysis underscores the association between the TyG index and an elevated risk of MACEs in CAD patients.